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KMID : 1059520110550060936
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Journal of the Korean Chemical Society
2011 Volume.55 No. 6 p.936 ~ p.939
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Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition
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Pravin V Badadhe
Asha V. Chate
Dattatraya G. Hingane
Pravin S. Mahajan
Namdev M. Chavhan
Charansingh H. Gill
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Abstract
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Thiamine hydrochloride (VB1) has been used as an acid catalyst in organic synthesis. One pot three component Biginelli condensation of dimedone, urea/thiourea and substituted aromatic aldehydes catalyzed by 10 mol % of thiamine hydrochloride (VB1) in solvent free condition under microwave irradiation in good to excellent yields has been investigated. Utilization of microwave irradiation, simple reaction conditions, short reaction time, ease of product isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.
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KEYWORD
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Thiamine hydrochloride, Biginelli reaction, Octahydroquinazolinone derivatives, Microwave-irradiation, Solvent-free
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